The monograph deals with the clinical and physiological aspects of the formation of artifical stable functional connections (ASFS) , their functioning in patients with motor disorders of central origin (hyperkinesis) and problems, associated with the consolidation of ASFS using non-specific connectors , Facilitate the consolidation of ties. ASPS is considered as a kind of matrix of long-term memory, which is based on changes in the functional state of the brain (excitability), between which the connection is closed during their combined electrical stimulation. The physiological and biochemical processes underlying the formation and storage of engrams of long-term memory, and associated synaptic and membrane mechanisms. are highlighted. The expediency of the methods used to form ASPS in the treatment of neurological diseases and the prospects for their use as a possible basis for compensation and restoration of impaired brain functions are argued. The monograph is intended for neurologists, physiologists, pharmacologists.