Training Manual . - Samara: SSTU, 2008. - 66 s. ISBN/ISSN:978-5-7964-1146-9. The basic principles of determination of general technological impurities in medicinal substances by reference and non-reference methods are considered. Examples of solving various problems arising both in the development of regulatory requirements for the purity of medicinal substances and in the practical implementation of the analysis. are given. Methods of preparation of reference solutions of impurities are given and some methodological recommendations for working with them. Methods for determining common technological impurities in medicinal substances are described and their essence is considered. Intended for students enrolled in specialty 02. 01. 01 "Chemistry" by specialization 02. 01. 32 "Pharmaceutical Chemistry" .