The presented manual contains information sufficient for a practical pediatrician about the causes (including classification and characteristics of toxic substances and physiological characteristics of the child's body), clinical manifestations and diagnosis of poisoning in children. Statistics are available. The organization and structure of assistance in case of poisoning, general principles of therapy are presented . Applications offer convenient tables and algorithms. When drawing up the manual, modern sources of literature, monographs, materials of periodicals . are used. The manual is intended for use in the practical activities of pediatricians, toxicologists, specialists of various specialties .