The study of internal diseases is one of the most important stages in the preparation of a doctor. Modern information about the etiology, pathogenesis, clinical picture and treatment of diseases of the internal organs in combination with the work of the student at the bedside of the patient form clinical thinking. This is the basis of future activity, the main part of which continues to be the study of the patient, which was especially emphasized by the great clinicians of the past. A modern clinician (including a therapist) should master the scientific method of thinking, learn to correctly interpret the results obtained, assess their reliability and evidence. Sections of the course of internal diseases are closely related to many basic sciences - general pathology, microbiology, biochemistry, pharmacology, knowledge of which is also necessary. Unconditional scientific achievements of the end of the 20th century, primarily the decoding of the human genome and the progress of molecular biology, are an important basis for progress in solving specific clinical problems of diagnosis, treatment and prognosis. All this should find a certain place in the understanding of the disease under study .. Over the past decade, new information technologies have begun to be actively used in medicine, allowing not only to receive the latest knowledge and exchange information, but also to systematize them effectively. Currently, there are many good domestic textbooks on internal diseases, following the classical traditions of domestic educational medical literature. However, the current rate of replenishment of medical knowledge and adherence to the principles of evidence-based medicine require the creation of a new generation of textbooks. It is very systematic , ....................................... by CM , CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC the maximum modernity of the information presented , A large number of illustrations, Tests, Reference materials.