The Siberian Oncological Journal . 2019 Vol. 18, No. 6”, created by the team of authors, is the most important scientific publication, which will become an indispensable source of information for oncology specialists, medical researchers and practicing doctors . This issue is a vivid testimony to the advanced achievements of modern medicine. Current issues of diagnosis, Treatment and Prevention of Cancer , especially in the Siberian region , where unique climatic and environmental features require a special approach to medical practice. This issue contains articles, research and clinical reviews that open new horizons in understanding the mechanisms of cancer development, as well as offering innovative therapies based on the latest scientific discoveries. Particular attention is paid to the issues of early diagnosis, improvement of methods of surgical intervention, chemotherapy and radiotherapy, as well as integrative approaches to the treatment of cancer patients. The authors - leading specialists from various medical institutions of Siberia and Russia - share the results of their research, which makes this issue not only relevant, but also practically valuable for those who are looking for fresh ideas and new solutions in the fight against cancer diseases. "Siberian Oncology Journal. 2019 Volume 18, No. 6" is not just a collection of articles, but a real window into the future of oncology, where scientific rigor and practical focus are combined. It raises important topics such as the genetic predisposition to cancer, the role of new biomarkers in diagnosis, and the prospects for the use of immunotherapy and targeted drugs. A special place is occupied by the discussion of regional aspects of cancer care, which makes this issue especially valuable for specialists working in the Siberian climate and the specifics of the local population. The book is intended for oncologists, clinical and laboratory researchers, students of medical universities, as well as for anyone interested in modern trends in the field of oncology. Its content will be of interest to both experienced professionals and young doctors starting their journey in this complex but extremely important field of medicine. Due to its clear structure and scientific depth, the journal allows the reader not only to get acquainted with the latest achievements, but also to find practical recommendations for implementation in clinical practice. The style of the authors is distinguished by clarity, accuracy and academic rigor, which makes the material available to a wide audience, while maintaining scientific value. This issue continues the tradition of the leading Siberian medical publication, which has long established itself as a reliable source of information for oncologists and medical specialists of the region and the country. Inspired by modern trends, the editorial board of the journal actively introduces new formats for submitting material, making it as convenient as possible for perception and application in practice. If you are looking for a book that combines scientific novelty, practical value and regional aspect, "Siberian Oncology Journal. 2019 Volume 18, No. 6" will be a real discovery for you. This publication is not only a source of knowledge, but also a platform for sharing experiences, discussing new methods and ideas that can change the approach to cancer treatment. In the World , where the fight against cancer requires constant updating of knowledge and innovative solutions , This is a step forward ,. which will help you stay up to date with the latest developments and scientific developments in the field of oncology , especially in the Siberian region , where every novelty can be a salvation for the patient.