The book describes new versions of the powerful, multifunctional integrated automation system of mathematical and scientific and technical calculations MATLAB 5. 0/5. 3 and a number of packages of its extensions, including Notebook, Symbolic and Simulink. Modern imaging technology of this system complements the extensive arsenal of numerical methods accumulated over the past three decades. The system has the properties of extensibility and adaptation to user tasks, is characterized by high speed of calculations and the ability to output in numerical, tabular and graphical form. Based on the work with vectors and matrices, it has effective means for solving problems in data processing, signal analysis and filtering, symbolic calculations and modeling of block-defined systems and devices.