The manual is intended for students, interns and clinical residents of higher medical educational institutions, as well as for cadets of certification, thematic cycles of improvement of doctors and specialization in gastroenterology within the faculty of postgraduate education . The manual presents the latest data on the pathogenesis, clinical, laboratory, instrumental signs of diseases of the biliary tract, such as gallbladder dysfunction and Oddi sphincter, cholecystitis, gallstone disease. The manual introduces the main clinical manifestations of diseases , Modern methods of research, such as fractional chromatic duodenal sensing, with microscopy and biochemical study of bile, Various radiographic methods, including CT and MRI, Ultrasound diagnostics. Particular attention is paid to training in understanding the diagnostic capabilities of these methods, to the clinical evaluation of the results The manual provides modern methods of therapy of diseases of the biliary tract with the use of modern drugs.