The textbook is devoted to computer modeling and optimization of technological processes and equipment in bio-, chemical and food technologies. The general approaches and methodology of computer modeling and optimization under conditions of uncertainty of the initial information are considered. The classification of models and methods of their construction is given, examples of derivation of equations of mathematical models of specific processes and devices of bio-, chemical and food technologies are given .. Particular attention in the manual is paid to the analytical method of constructing models and the methodology of simulation modeling . The article discusses the formulation of one- and two-stage problems of optimization of technological processes and devices with probabilistic and 'hard' constraints in the presence of uncertainty of individual model parameters and mode variables. Methods and algorithms for their solution are given. The manual is intended for full-time and part-time students and undergraduates: 665400 - Energy and resource-saving processes in chemical technology, petrochemistry and biotechnology, 655800 - Food engineering, 551800 - Technological machines and equipment