This volume reviews cutting-edge innovations in blockchain technology that are propelling the healthcare industry into a new era of efficiency and security. It brings 14 reviews contributed by experts in blockchain and Web3 technologies into a single volume. Each contribution includes a summary for easy understanding and scientific references for advanced readers. Key Themes: Empowering Decentralized Healthcare: Learn about the future of decentralized healthcare, powered by blockchain, ensuring a seamless and patient-centric experience. Clinical Trials: Discover how blockchain is reshaping clinical trials, offering a glimpse into a future of optimized medical research. Data Security: Uncover the strategic use of blockchain in securing vital clinical trials data, ensuring confidentiality and integrity at every step. Blockchain-based Healthcare delivery: Delve into a comprehensive review of blockchain technology in the health sector, revealing its potential to transform healthcare systems with efficient and precise solutions. Predict, Prevent, and Protect: Understand how blockchain technology serves as a predictive tool, aiding in the prevention and control of the spread of COVID-19. This volume is a must-read for healthcare practitioners and administrators seeking to harness the power of blockchain in medicine and healthcare. It also provides information for researchers and business professionals who want to understand the innovative role of blockchain technology in the healthcare sector.