Maintaining the high standard of quality that made previous editions so successful, this totally revised and updated text incorporates the most recent advances in basic and clinical immunology-emphasizing diagnostic and clinical applications as well as state-of-the-art discussions of the principles and strategies for modulation of the immune respon;Basic ImmunologyIntroductionGabriel VirellaCells and Tissues Involved in the Immune ResponseGabriel Virella and Jean-Michel GoustMajor Histocompatibility ComplexJean-Michel GoustThe Induction of an Immune Response: Antigens, Lymphocytes and Accessory CellsGabriel Virella and Barbara E. BiererImmunoglobulin StructureGabriel VirellaBiosynthesis, Metabolism, and Biological Properties of ImmunoglobulinsGabriel VirellaGenetics of ImmunoglobulinsJanardan P. PandeyAntigen-Antibody ReactionsGabriel VirellaThe Complement SystemRobert BoackleLymphocyte Ontogeny and Membrane MarkersVirginia M. Litwin and Jean-Michel Goust Cell-Mediated ImmunityBarbara E. Bierer, Jean-Michel Goust, and Gabriel VirellaThe Humoral Immune Response and Its Induction by Active ImmunizationGabriel VirellaPhagocytic CellsGabriel VirellaInfections and ImmunityGabriel VirellaDiagnostic ImmunologyDiagnostic ImmunologyGabriel Virella and Virginia M. LitwinClinical ImmunologyTolerance and AutoimmunityGeorge C. Tsokos, Jean-Michel Goust, and Gabriel VirellaOrgan-Specific Autoimmune DiseasesGabriel Virella and Jean-Michel GoustSystemic Lupus ErythematosusGeorge C. Tsokos and Jean-Michel GoustRheumatoid ArthritisJean-Michel Goust and Gabriel VirellaHypersensitivity ReactionsGabriel VirellaIgE-Mediated (Immediate) HypersensitivityJean-Michel Goust and Albert F. Finn, Jr.ImmunohematologyGabriel Virella and Mary Ann SpiveyImmune Complex DiseasesGabriel Virella and George C. TsokosImmune System ModulatorsPhilip D. Hall, Jean-Michel Goust, and Gabriel VirellaTransplantation ImmunologyGabriel Virella, Richard Knight, and Jonathan BrombergTumor ImmunologySebastiano Gattoni-CelliMalignancies of the Immune SystemGabriel Virella and Jean-Michel GoustImmunodeficiency Disea