This volume collects papers based on plenary and invited talks given at the 50th Barrett Memorial Lectures on Approximation, Applications, and Analysis of Nonlocal, Nonlinear Models that was organized by the University of Tennessee, Knoxville and held virtually in May 2021. The three-day meeting brought together experts from the computational, scientific, engineering, and mathematical communities who work with nonlocal models. These proceedings collect contributions and give a survey of the state of the art in computational practices, mathematical analysis, applications of nonlocal models, and explorations of new application domains. The volume benefits from the mixture of contributions by computational scientists, mathematicians, and application specialists. The content is suitable for graduate students as well as specialists working with nonlocal models and covers topics on fractional PDEs, regularity theory for kinetic equations, approximation theory for fractional diffusion, analysis of nonlocal diffusion model as a bridge between local and fractional PDEs, and more.