The second volume in the series presents ground-breaking advances of Viktor Frankl’s logotherapy and existential analysis, with emphasis on the discovery of meaning as central to coping, resilience, and growth. Noted contributors from around the world present empirical and case study evidence for the importance of meaning in diverse populations and settings, as well as theoretical and philosophical perspectives on Frankl’s body of thought. The book opens with a historical perspective of the development of logotherapy and personal experiences of those close to Frankl. A section on the amelioration of suffering provides insights into moral injury and finding meaning in blows of fate (unavoidable suffering, death, the injustice of poverty, and international conflict). Powerful case studies address Frankl’s tragic triad (guilt, suffering, death): facing the end of life, PTSD, childhood sexual abuse/neglect, and suicide prevention. Empirical studies address the search for purpose in life, qualities of meaning among the gifted, and service motivation in college students. Meaning-centered approaches are applied to working with youth and adults in schools and the workplace. Philosophical applications of logotherapy connect Frankl’s theory with Buddhist thought and a flaw in the nature vs. nurture theory; the dimensional ontology is expanded into four dimensions. Book reviews evaluate topics of interest to logotherapists.