The occurrences of both injury and death that take place on the job are a significant public health problem in the United States, causing a substantial human and economic burden. Traumatic Injury Research at NIOSH is the sixth report in the series Reviews of Research Programs of the National Institute for Occupational Safety and Health. The Committee to Evaluate the NIOSH Traumatic Injury Research Program found the program’s research during 1996-2005 (the evaluation period for this review) relevant to reducing the burden of traumatic injury in the workplace and to have contributed to improvements in worker health and safety. To continue to reduce injuries and deaths to workers due to trauma, the committee recommended that the TI Research Program continue setting goals within the program’s scope and resources; work with other federal agencies that support injury prevention and control research to outline areas of collaboration; embark on a program to increase the visibility of traumatic injury research; develop a strategic plan for evaluating its research-to-practice efforts and for building the capacity to carry out these efforts; and consider research on the safety impacts of changes in the nature of work as well as intervention research targeting organization policies and practices.