Doctors at Hopedale Emergency Hospital are giving patients a second chance at life. And finally, they get a second chance at the love everyone dreams of. Noah is an emergency room doctor with a heart condition: he is lonely. Since his wife died four years ago, he has been raising his young son with the help of his equally lonely sister, Rachel. When he meets a beautiful young radiologist, he instantly falls in love and begins to pursue her. Kalinda is the eldest of five siblings, although the girl looks more like their mother. However, she has a crush on the tall, dark and handsome Dr. Bonner and is over the moon when he asks her out on a date. A hot night spent together is interrupted by Kalinda's marital problems. Will Noah and Kalinda be able to turn their instant love into a life together?