The manual is intended for practical classes in higher mathematics in 1 semester . The content of the manual corresponds to the work program of the discipline Higher Mathematics for students of the Institute of Biology and Biomedicine studying in specialties 30. 05. 01 Medical biochemistry, 30. 05. 02 Medical Biophysics, 30. 05. 03 Medical Cybernetics. The manual can also be used when conducting practical classes in mathematics in 1 semester for students studying in the areas of training 05. 03. 06 Ecology and Environmental Management, 06. 03. 01 Biologies. The work contains tasks for classroom and independent classes, control questions for preparing for classes, samples of solving some tasks. Here is a list of questions to set off and an approximate list of tasks that you need to be able to solve to pass the set-off.