The textbook is devoted to the topical issue of modern medicine - the prevention of the development of a severe and widespread disease - gallstone disease. Particular attention is paid to practical recommendations based on the achievements of science, which include knowledge of the so-called pre-stone states, when the development of gallstones is prevented with the help of available therapeutic and prophylactic measures. In addition, the principles of laboratory and instrumental diagnostics, as well as the treatment of this disease are given, real advice is given on the correct regulation of the mode of work depending on professional duties, rational diet. The training manual is intended for students studying in the specialty of higher profile education "Medicine", as well as for therapists .