Methodological approaches to the formation of the mechanism of public-private partnership . The mechanism of using public-private partnership schemes to ensure innovative development of the region is considered. Methodology of calculation of state participation in innovative development of business sector in the conditions of economic crisis. Testing of the technique was carried out at enterprises of the North-West Federal District. The calculations were carried out by the employees of the Department of Economics and Management at the enterprises of small and medium-sized businesses of Moscow State Technical University on the basis of data from more than 300 enterprises of the North-West Federal District. For economists of various specializations, students and postgraduates of economic universities .