The monograph is devoted to the construction, analysis and application of combinatorial plans in the tasks of the multifactorial experiment. Latin and incomplete plans, frequency squares, schemes with variable parameters, orthogonal and balanced tables. are considered. New types of quasi-orthogonal plans, plans for the study of sequential effects, taking into account the order and residual effects, etc. The principles of composite combinatorial planning . are developed Examples from biology, medicine, engineering, computer science, ergonomics. are given. The book is intended for a wide range of researchers engaged in the staging of a multifactorial experiment.