We provide a step-by-step guide to medically sound early treatments that have a reasonable probability of success in this emergency pandemic. There are oral medications that are approved for other conditions, but not yet proven to be efficacious specifically for COVID-19 by the U.S. Food and Drug Administration. In the global pandemic emergency, large scale randomized clinical trials have not been feasible in the face of such critical illness. The National Institutes of Health was slow to recommend treatment outside of the hospital. And for the first nearly two years of the pandemic, there were no oral medications specifically approved for outpatient COVID-19 treatment, even though the mortality rate once patients require hospitalization isunacceptably high.Thus, treatment administered outside of the hospitalized setting should be under the supervision of a physician or licensed medical professional who is knowledgeable in the use of the medications and the monitoring approach for ambulatory, home-based COVID-19 as described in this guide. Patients who worsen in any way should seek emergency room evaluation immediately.