Since its inception in 2019, the MIND conference series has featured some of the most innovative and fascinating basic and applied research in the flourishing research area centered on machine learning and computational intelligence, image processing and computer vision, network and cybersecurity and data sciences and big data. This tradition of exemplary interdisciplinary research has been kept alive in 2021 as evident through the imaginative, exciting and diverse set of papers spanning the fields of artificial intelligence, data science, computer science, engineering, computer vision and linguistics. The MIND 2021 conference program featured a rich portiere of original research embodied through oral presentations, posters, invited talks and workshops. In all, we received 273 submissions, and each paper was reviewed by at least two expert reviewers (most papers received three reviews). Seventy-one out of the 273 regular papers were accepted as oral presentations (26 percent which is the lowest from all the previous MIND conferences).